Evidence supporting the use of: Cholic acids (unspecified)
For the body system: Gall Bladder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cholic acids, which are primary bile acids produced in the liver, have a well-established scientific role in supporting the gall bladder and overall biliary system. They are critical for the emulsification and absorption of dietary fats and fat-soluble vitamins. In clinical practice, synthetic or purified bile acids (including cholic acid itself) are used as therapeutic agents in certain hepatobiliary disorders. Specifically, cholic acid is FDA-approved for the treatment of rare bile acid synthesis disorders due to single enzyme deficiencies, such as bile acid synthesis defects and peroxisomal disorders. By supplementing with cholic acid, these patients can restore a healthier bile acid pool, promote bile flow, and reduce the accumulation of hepatotoxic intermediates.

Furthermore, bile acids in general—including cholic acid—can help dissolve certain types of gallstones (especially cholesterol stones) and may be used to manage gallbladder dysfunction, although ursodeoxycholic acid is more commonly used for this purpose. The scientific evidence for cholic acid’s role in gallbladder health is robust in specific clinical scenarios, with multiple studies and regulatory approvals backing its use for inborn errors of bile acid metabolism. However, its use as a general supplement for gallbladder health in otherwise healthy individuals is less supported by direct evidence. Overall, the scientific validation for cholic acid’s supportive role in the gall bladder system is strong for specific medical indications.

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