Evidence supporting the use of: Dehydrocholic acid
For the body system: Gall Bladder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Dehydrocholic acid is a synthetic bile acid derivative that has been utilized in medicine primarily as a choleretic agent, meaning it promotes the production and flow of bile from the liver and gallbladder. Its use is particularly relevant in conditions where bile flow needs to be increased, such as in some forms of cholestasis or after certain types of gallbladder surgery. Historically, dehydrocholic acid has been employed to manage biliary dyskinesia and to prevent the formation of gallstones by improving bile flow. There is moderate scientific evidence supporting its efficacy in stimulating bile secretion and enhancing the excretion of bile acids, cholesterol, and other organic anions. Clinical studies, primarily from the mid-20th century, documented its ability to increase bile production and improve symptoms in patients with biliary tract disorders. However, more recent research is limited and its use has declined with the advent of newer, more effective agents such as ursodeoxycholic acid. Despite this, dehydrocholic acid is still recognized in some pharmacopeias and is occasionally used in Europe and Asia for its choleretic effects. Its mechanism of action is well-understood, and its role in enhancing bile flow is documented, but high-quality, contemporary clinical trials are lacking. Therefore, while the use of dehydrocholic acid to support gallbladder function is based on scientific principles, the strength of evidence is moderate rather than robust.

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Other body systems supported by dehydrocholic acid

Digestive System
Gall Bladder
Gastrointestinal Tract
Hepatic System
Liver

Products containing dehydrocholic acid

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