Evidence supporting the use of: Guggulsterone
For the body system: Gall Bladder

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Guggulsterone is a plant sterol derived from the resin of the Commiphora mukul tree, commonly known as guggul. Its use for supporting the gall bladder and promoting bile flow is primarily rooted in Ayurvedic tradition, where guggul has been used for centuries to address issues related to digestion and lipid metabolism. In Ayurveda, guggul is considered to have properties that help dissolve and mobilize "ama" (toxins) and promote the health of the liver and gall bladder, indirectly supporting bile secretion and fat metabolism.

Scientifically, there is limited direct evidence supporting guggulsterone for specific gall bladder health or bile flow enhancement. Most modern research on guggulsterone has focused on its cholesterol-lowering effects and its role as a farnesoid X receptor (FXR) antagonist, which can influence bile acid metabolism. However, these studies have not conclusively demonstrated its efficacy in treating or preventing gall bladder disorders such as gallstones or biliary dyskinesia.

In summary, while guggulsterone's use for the gall bladder is supported by a long history of traditional use, modern clinical validation for this specific application is lacking. The evidence is primarily traditional, with only moderate support from scientific mechanisms and no robust clinical trials directly linking guggulsterone to improved gall bladder health.

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