Evidence supporting the use of: Oregon Barberry
For the body system: Gall Bladder

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Oregon Barberry (Berberis aquifolium, also known as Mahonia aquifolium) has a long history of use in traditional herbal medicine, particularly among Native American and later Western herbalists. It has been used to support digestive health, stimulate bile flow, and aid in liver and gallbladder function. The primary active compound in Oregon Barberry is berberine, an alkaloid also found in related plants like Goldenseal and Barberry (Berberis vulgaris). Historically, herbalists used Oregon Barberry to address conditions believed to be associated with sluggish liver or gallbladder, such as poor digestion or jaundice. While laboratory and animal studies have demonstrated that berberine can stimulate bile secretion and has hepatoprotective (liver-protecting) effects, direct scientific studies specifically on Oregon Barberry and its effects on the human gallbladder are lacking. Most of the support for its use comes from traditional practice and extrapolation from studies on berberine-containing plants in general. There is insufficient clinical trial evidence to conclusively support its efficacy for gallbladder health in humans. Therefore, its use to support the gallbladder system is primarily justified by traditional knowledge, with modest evidence based on its chemistry and related research.

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