Evidence supporting the use of: Cynarin
For the health condition: Gall Bladder (sluggish or removed)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Cynarin is a compound found primarily in artichoke (Cynara scolymus) and has a long history of traditional use in European herbal medicine for supporting liver and gall bladder health. Traditional herbalists have used artichoke extracts, including cynarin, as a choleretic—meaning it is believed to stimulate the production and flow of bile from the liver and gall bladder. This use is rooted in folk medicine practices aimed at relieving symptoms of indigestion, "sluggish" gall bladder, and to support digestion after gall bladder removal. Scientifically, there is some evidence from animal and in vitro studies that cynarin and artichoke extracts can increase bile secretion. A few small human studies have also indicated improved bile flow and mild benefits for digestion. However, robust clinical trials specifically assessing cynarin for gall bladder dysfunction or post-cholecystectomy support are limited. The European Medicines Agency acknowledges traditional use of artichoke leaf for "supportive treatment of dyspeptic complaints." Overall, the use of cynarin for gall bladder support is primarily justified by tradition, with some preliminary scientific findings but lacking strong, high-quality clinical evidence. Its use after gall bladder removal is based on the rationale of supporting bile production, but direct evidence for this application is minimal. Thus, the strength of evidence is modest.

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Products containing cynarin

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