Evidence supporting the use of: Pancreatin
For the health condition: Gall Bladder (sluggish or removed)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pancreatin is a mixture of digestive enzymes (primarily amylase, lipase, and protease) derived from the pancreas of pigs or cows. It is used to aid digestion in individuals who have pancreatic insufficiency, but its use can also extend to those with gallbladder issues, especially after gallbladder removal (cholecystectomy). The rationale lies in the fact that the gallbladder stores and concentrates bile, which is necessary for fat digestion. When the gallbladder is sluggish or removed, bile is delivered less efficiently to the small intestine, potentially impairing fat digestion. Although pancreatin does not replace bile, it contains lipase, which helps break down fats, thereby compensating partially for the reduced efficiency in fat digestion.

Several clinical studies and expert guidelines support the use of pancreatin (pancreatic enzyme replacement therapy) after cholecystectomy in patients who experience steatorrhea (fatty stools) or digestive discomfort. For example, a study in the World Journal of Gastroenterology (2017) discusses the benefit of enzyme supplementation for post-cholecystectomy syndrome. However, the evidence is not robust for all patients; most benefit is seen in those with clear symptoms of fat malabsorption. Professional sources like the American College of Gastroenterology recognize enzyme supplementation as a reasonable option for selected cases. In summary, while pancreatin is not universally indicated for all gallbladder-related issues, there is moderate scientific validation for its use in select patients, particularly those with symptoms indicative of impaired fat digestion.

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