Evidence supporting the use of: Dehydrocholic acid
For the health condition: Gall Stones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dehydrocholic acid is a synthetic bile acid derivative that has been used in the management of gallstones, particularly as a choleretic agent—that is, a substance that increases bile secretion. The rationale for its use is based on its ability to enhance bile flow and modify bile composition, thereby potentially aiding in the dissolution of cholesterol gallstones. There is some scientific literature from the mid-20th century that investigated dehydrocholic acid for this purpose, often in the context of nonsurgical management of gallstones. For example, studies from the 1950s and 1960s suggested that dehydrocholic acid could increase the output of bile and make it less lithogenic (less prone to stone formation). However, the evidence base is limited, with most studies being small, dated, and not rigorously controlled by modern standards. More recent and robust evidence has favored other bile acids, such as ursodeoxycholic acid, which have largely supplanted dehydrocholic acid in clinical practice for gallstone dissolution. As a result, while there is historical scientific justification for its use, the strength and quality of evidence is low, and dehydrocholic acid is not considered a first-line therapy for gallstones today.

More about dehydrocholic acid
More about Gall Stones

Other health conditions supported by dehydrocholic acid

Gall Bladder (sluggish or removed)
Gall Stones

Products containing dehydrocholic acid

We currently have no products on Vitabase that contain this ingredient.