Jamaican Sarsaparilla (Smilax regelii or related species) has been used in traditional herbal medicine in the Caribbean for a wide range of ailments, including as a "blood purifier" and for liver and kidney health. In Jamaican folk medicine, sarsaparilla is sometimes recommended for conditions related to the liver and gallbladder, which may include gall stones, based on the general belief in its detoxifying and anti-inflammatory properties. However, the specific use of Jamaican Sarsaparilla for the treatment or support of gall stones is not well-documented in either traditional texts or contemporary herbal compendiums. There are anecdotal reports and some traditional practitioners who recommend it for this purpose, but these are not widely supported by detailed traditional records or clinical use guidelines.

Scientifically, there is little to no evidence supporting the efficacy of Jamaican Sarsaparilla for dissolving or preventing gall stones. Phytochemical studies have shown that sarsaparilla contains saponins and other compounds, but no robust clinical trials or pharmacological studies have been conducted to evaluate its effects on gall stone formation, dissolution, or gallbladder health. Therefore, while the use of Jamaican Sarsaparilla for gall stones is rooted in tradition, the evidence is weak and largely anecdotal, with no scientific validation.