Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Trichosanthes, particularly species such as Trichosanthes kirilowii and Trichosanthes cucumerina, has a long history of use in traditional Chinese medicine and other Asian herbal systems. Traditionally, the fruit, root, or seeds have been used for various ailments, including respiratory conditions, fever, and inflammatory diseases. In some folk traditions, Trichosanthes is believed to have benefits for the liver and gallbladder, and it has occasionally been used in compound herbal formulas aimed at supporting gallbladder health or treating gallstones (cholelithiasis). The rationale is often based on its reputed ability to "clear heat" and "resolve phlegm" or "dissolve masses."

However, there is a paucity of rigorous scientific evidence supporting the efficacy of Trichosanthes specifically for gallstone dissolution or prevention. While a few animal studies and in vitro investigations suggest that certain saponins and other constituents of Trichosanthes may have anti-inflammatory or hepatoprotective effects, direct evidence for its use in gallstone treatment is lacking. Most references to its use for gallstones are anecdotal or based on traditional herbal texts, rather than controlled clinical trials. Therefore, its application for gallstone management remains within the realm of traditional practice, with minimal scientific validation.

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