Evidence supporting the use of: Vitamin A
For the body system: Gastrointestinal Tract
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin A is scientifically recognized as essential for maintaining the integrity and function of the gastrointestinal (GI) tract, particularly the epithelial lining. Vitamin A plays a critical role in cell differentiation, especially in mucosal epithelial cells lining the gut, which form a barrier against pathogens and facilitate nutrient absorption. Deficiency in vitamin A can result in impaired mucosal barriers, increasing susceptibility to infections and compromising nutrient uptake. Several studies, primarily in the context of deficiency, demonstrate that restoring adequate vitamin A levels can help restore mucosal health and immune function in the gut. However, evidence that supplementation above recommended dietary intake provides additional gastrointestinal benefits in otherwise healthy individuals is limited. Clinical use is primarily focused on preventing or correcting deficiency, especially in populations at risk (e.g., malnourished children or those with malabsorptive disorders). In summary, vitamin A’s role in GI tract health is well-founded at the physiological and cellular level, but robust clinical trials demonstrating therapeutic effects for GI disorders in non-deficient populations are lacking.
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