American Liverleaf (Hepatica americana), also known as liverwort or hepatica, has a history of use in North American and European traditional herbal medicine. Its name derives from the Doctrine of Signatures, an old concept that suggested plants resembling certain body organs could be used to treat ailments of those organs. Historically, American Liverleaf was used as a tonic for liver and digestive issues, and some folk traditions extended its application to various inflammatory conditions, including oral health issues such as gingivitis and mouth sores. However, these uses are based largely on anecdotal reports, herbal compendia, and early pharmacopoeias rather than on systematic scientific investigation. There is little to no modern clinical research specifically evaluating the efficacy of American Liverleaf for gingivitis or oral health in general. Thus, its use for gingivitis is rooted in tradition rather than scientific validation. While it may possess some general anti-inflammatory or astringent properties, as suggested by its historical use for mucous membrane inflammation, the quality and quantity of evidence supporting its benefit in gingivitis are minimal. Contemporary herbal medicine references may mention its historical use, but it is not widely recommended in modern practice for this purpose, and there are no robust clinical trials to substantiate its efficacy.