Evidence supporting the use of: Ananain
For the health condition: Gingivitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ananain is a cysteine protease enzyme derived from the stem of the pineapple plant (Ananas comosus). Its use in treating or supporting gingivitis is based on its proteolytic (protein-digesting) activity, which can help degrade necrotic tissue and reduce biofilm formation in the oral cavity. Several in vitro studies have shown that enzymes like ananain and bromelain can disrupt dental plaque and may have mild anti-inflammatory properties. A handful of small-scale clinical studies and pilot trials have indicated a potential benefit for reducing gingival inflammation and plaque index scores when enzyme-containing mouthwashes or gels are used adjunctively with regular oral hygiene.

However, the clinical evidence remains limited and of low quality. Most studies have been short-term, involved small sample sizes, and often combined ananain with other enzymes such as bromelain or papain, making it difficult to isolate its specific effect. Systematic reviews have not established a strong consensus for the routine use of such enzymes in managing gingivitis, and major dental organizations do not currently recommend ananain as a primary therapy. In summary, while there is some emerging scientific evidence for its adjunctive benefit, it is not robust, and more well-designed clinical trials are needed.

More about ananain
More about Gingivitis

Other ingredients used for Gingivitis

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Allium tuberosum
Aloe vera
Alpha hydroxy acids
alpha-terpineol
American Liverleaf
Amor seco
anamu
ananain
anthocyanidins
anthocyanins
apple cider vinegar
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Ardisia
Asam gelugor
aster root
avens
babchi
Bacillus
bacteria
balsam
banyan
Baphicacanthus cusia
Barleria
basil
bayleaf
bee hive
bee pollen
bee propolis
bentonite
benzyl isothiocyanate
betel
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Bifidobacterium longum
bio ecolian (proprietary)
bioflavonoids
bitter grass
black garlic
black nightshade
black pepper
black seed
black walnut
blackberry
blackboard tree
Blepharis
Blue-Green Alage
Bombax
Borassus aethiopum
borassus palm
borneol
Boswellic Acid
bromelain
Broussonetia
Butea monosperma
Caesalpinia crista
cajuput
Calendula
Camellia sinensis
Carthamus
carvacrol
caryophyllene
cat's claw
catechins
cayenne pepper
Celosia
Centella asiatica
Centipeda
chamomile
chlorophyllin
Cinnamomum
cinnamon
Cistus
citrus bioflavonoids
citrus sinensis (proprietary)
Clerodendrum trichotomum
coconut milk
coconut oil
commiphora
copaiba oil
Coptis chinensis
corktree
costus
Dianthus
Dichrostachys glomerata
elephant\'s head
ellagic acid
empresstree
enzymes blend (proprietary)
epigallocatechin gallate (EGCG)
eugenol
Euphorbia
Evodia
ferula assafoetida
Ficus religiosa
flavans
flavonols
flavonones
frankincense
fucoidan
fulvic acid
Galangal
Gallesia
gallic acid
Gambir
garlic
genipap
geraniol
geranium
ginger
Glechoma hederacea
glyceryl monolaurate
Glycolic acid
Gnaphalium
goldenseal
gooseberry
gotu kola
grape
Greek mountain tea
green tea
Guava
gum
Helicteres isora
Horsemint
Indian bael
Indian coraltree
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iridoid glycosides
iridoids
Isatis
isoquinoline alkaloids
Kefir
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labrador tea
lactiplantibacillus plantarum
Lactobacillus casei
Lactobacillus gasseri
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Lactobacillus reuteri
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Lactoferrin
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lemon
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liverwort
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mangostin
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melaleuca alternifolia
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Nimbidin
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onion
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oregano
oregon grape
Orris
pagoda tree
parsley
paw paw
Pentacyclic triterpenoids
peony
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Peppermint
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phellodendron amurense
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polyphenols
Portulaca
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procyanidol
Propolis
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raspberry
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rosmarinic acid
Rubus
rutin
sage
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schizonepeta
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slippery elm bark
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Sophora
specialized pro-resolving mediators (SPMs)
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Stereospermum
Streptococcus oralis
Streptococcus salivarius
streptococcus thermophilus
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sweet flag
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typhonium
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zanthoxylum
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Products containing ananain

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