Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Grape and its derivatives, particularly grape seed extract and red grape polyphenols (such as resveratrol), have been investigated for their potential role in the management of gingivitis. The scientific rationale behind their use lies primarily in their antioxidant and anti-inflammatory properties. Several in vitro studies have demonstrated that grape polyphenols can inhibit the growth of oral pathogens associated with periodontal disease, such as Porphyromonas gingivalis. Moreover, these compounds have been shown to reduce oxidative stress and modulate inflammatory responses within gingival tissues.

A handful of small clinical trials and animal studies have indicated that grape extracts may help decrease gingival bleeding, plaque accumulation, and markers of inflammation when used as an adjunct to conventional oral hygiene. For example, a double-blind, placebo-controlled study reported modest improvements in gingival indices in subjects using mouthwashes containing grape seed extract. However, the quality, size, and duration of these studies are generally limited, and results are not uniformly positive.

In summary, while there is some scientific evidence suggesting that grape-derived compounds may benefit gingivitis due to their anti-inflammatory and antimicrobial effects, the overall evidence base remains preliminary (evidence rating: 2/5). Larger, well-designed clinical trials are needed before grape or its extracts can be recommended as a standard treatment for gingivitis.

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Other ingredients used for Gingivitis

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