Evidence supporting the use of: Lysozyme
For the health condition: Gingivitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lysozyme is an enzyme naturally present in human secretions such as saliva and tears, and is known for its antibacterial properties, primarily through its ability to hydrolyze the peptidoglycan in bacterial cell walls. Its use in oral care products for gingivitis is based on this antimicrobial action. Several in vitro studies have demonstrated that lysozyme can reduce bacterial load, including oral pathogens implicated in periodontal disease. Some clinical studies and patents report the inclusion of lysozyme in mouthwashes or toothpastes, often in combination with other enzymes or antimicrobials, suggesting a possible adjunctive benefit in reducing gingival inflammation and plaque levels. However, high-quality, large-scale randomized controlled trials specifically evaluating lysozyme as a monotherapy for gingivitis are limited. Most available clinical evidence is preliminary, with small sample sizes or used in combination formulas, making it difficult to isolate the effect of lysozyme alone. Therefore, while there is a scientific rationale and some supportive evidence for lysozyme's use in gingivitis, the strength and quality of clinical evidence remain modest, justifying a rating of 2 out of 5.

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Products containing lysozyme

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