Evidence supporting the use of: Naphthoquinones
For the health condition: Gingivitis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Naphthoquinones, specifically 1,4-naphthoquinone derivatives such as lawsone (from Lawsonia inermis, henna) and plumbagin (from Plumbago species), have been investigated for their antimicrobial and anti-inflammatory properties. Several in vitro studies demonstrate that naphthoquinones possess significant activity against oral pathogens, including those implicated in gingivitis, such as Porphyromonas gingivalis and Streptococcus mutans. These compounds disrupt bacterial cell membranes, inhibit biofilm formation, and modulate inflammatory responses in gingival tissues.

There are small-scale clinical studies and animal models suggesting that formulations containing naphthoquinones may reduce plaque accumulation and gingival inflammation. For example, plumbagin-containing gels have been tested in experimental gingivitis models with some reduction in clinical parameters of gingival inflammation (source). However, robust, large-scale randomized controlled trials in humans are lacking.

In summary, the use of naphthoquinones for gingivitis is supported by promising laboratory and preliminary clinical evidence, particularly due to their antimicrobial and anti-inflammatory actions. The current level of scientific validation is moderate (evidence rating: 3), with further research needed to establish efficacy and safety in clinical practice.

More about Naphthoquinones
More about Gingivitis

Other ingredients used for Gingivitis

ajoene
aloe vera
anthocyanins
basil
myrobalan
betel
bifidobacterium bifidum
bifidobacterium longum
bio ecolian (proprietary)
bisabolol
black garlic
black pepper
black walnut
blackberry
Indian frankincense
bromelain
cat's claw
catechins
chamomile
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coating
coconut milk
Coptis chinensis
turmeric
epigallocatechin gallate (EGCG)
flavonols
ginger
goldenseal
gooseberry
gotu kola
grape
greek mountain tea
onion
green tea
lactobacillus casei
lactobacillus gasseri
lactobacillus lactis
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus salivarius
lactoferrin
lactoperoxidase
lauric acid
lemon
licorice root
microbial enzymes (proprietary)
monolaurin
moringa
mustard seed
orange
oregano
oregon grape
parsley
peppermint oil
phellodendron amurense
quercetin
raspberry
rutin
sage
schizonepeta
slippery elm bark
specialized pro-resolving mediators (SPMs)
streptococcus thermophilus
triphala
vitamin C
vitamin E
xylitol
zinc
bentonite
typhonium
Indian bael
ferula assafoetida
commiphora
blackboard tree
caesalpinia crista
bee pollen
peony
myrrh
sweet flag
morinda
trichosanthes
zanthoxylum
polyphenols
trace minerals
fulvic acid
menthol oil
aster root
paw paw
white oak
melaleuca alternifolia
enzymes blend (proprietary)
cayenne pepper
geranium
Avens
Apple Cider Vinegar
Alpha-terpineol
Ardisia
acacia
Allicin
Anamu
Ajuga
Alpha Hydroxy Acids
American Liverleaf
Asam gelugor
anthocyanidins
Acemannan
Ananain
Allium tuberosum
Amor seco
Arani
Bee Propolis
Black Seed
Babchi
Baphicacanthus cusia
Broussonetia
Blepharis
Balsam
Boswellic Acid
Bayleaf
Butea monosperma
Barleria
Bitter Grass
Bee hive
Banyan
Bioflavonoids
Black Nightshade
Bombax
Borassus Palm
Borassus aethiopum
Bacteria
Blue-Green Alage
Bacillus
benzyl isothiocyanate
Borneol
Camellia sinensis
Caryophyllene
Calendula
Cinnamomum
Clerodendrum trichotomum
Chlorophyllin
coconut oil
Carvacrol
Cajuput
Centella asiatica
Centipeda
Cistus
Corktree
Costus
Carthamus
Copaiba Oil
Celosia
Dianthus
Dichrostachys glomerata
Ellagic Acid
Empresstree
Elephant's Head
Euphorbia
Eugenol
Flavonones
Garlic
Galangal
Mustard
Mallow
Metal Salt
Sumac
Zucchini

Products containing Naphthoquinones

We currently have no products on Vitabase that contain this ingredient.