Evidence supporting the use of: Piper nigrum
For the health condition: Gingivitis
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Piper nigrum (black pepper) has a long history of use in traditional medicine systems, including Ayurveda and Traditional Chinese Medicine, for a variety of oral health issues, including gingivitis. In traditional practices, black pepper has been valued for its antimicrobial, anti-inflammatory, and antioxidant properties, and is sometimes included in herbal formulations or tooth powders intended to support gum health and reduce oral inflammation.
Scientifically, there is limited direct evidence evaluating the efficacy of Piper nigrum specifically for gingivitis. A few in vitro studies have demonstrated that extracts of black pepper possess antimicrobial activity against common oral pathogens, and piperine—the main bioactive alkaloid—has shown anti-inflammatory effects in various models. However, clinical trials or robust preclinical studies directly assessing the impact of black pepper or its constituents on gingivitis in humans are lacking.
In summary, the use of Piper nigrum for gingivitis is primarily justified by traditional practices and anecdotal reports, with limited low-level scientific support. Until more rigorous clinical studies are conducted, its use for this purpose should be regarded as traditional rather than evidence-based.
Other ingredients used for Gingivitis
AcaciaAcemannan
Ajoene
Ajuga
Allicin
Allium tuberosum
Aloe vera
Alpha hydroxy acids
alpha-terpineol
American Liverleaf
Amor seco
anamu
ananain
anthocyanidins
anthocyanins
apple cider vinegar
Arani
Ardisia
Asam gelugor
aster root
avens
babchi
Bacillus
bacteria
balsam
banyan
Baphicacanthus cusia
Barleria
basil
bayleaf
bee hive
bee pollen
bee propolis
bentonite
benzyl isothiocyanate
betel
Bifidobacterium bifidum
Bifidobacterium longum
bio ecolian (proprietary)
bioflavonoids
bitter grass
black garlic
black nightshade
black pepper
black seed
black walnut
blackberry
blackboard tree
Blepharis
Blue-Green Alage
Bombax
Borassus aethiopum
borassus palm
borneol
Boswellic Acid
bromelain
Broussonetia
Butea monosperma
Caesalpinia crista
cajuput
Calendula
Camellia sinensis
Carthamus
carvacrol
caryophyllene
cat's claw
catechins
cayenne pepper
Celosia
Centella asiatica
Centipeda
chamomile
chlorophyllin
Cinnamomum
cinnamon
Cistus
citrus bioflavonoids
citrus sinensis (proprietary)
Clerodendrum trichotomum
coconut milk
coconut oil
commiphora
copaiba oil
Coptis chinensis
corktree
costus
Dianthus
Dichrostachys glomerata
elephant\'s head
ellagic acid
empresstree
enzymes blend (proprietary)
epigallocatechin gallate (EGCG)
eugenol
Euphorbia
Evodia
ferula assafoetida
Ficus religiosa
flavans
flavonols
flavonones
frankincense
fucoidan
fulvic acid
Galangal
Gallesia
gallic acid
Gambir
garlic
genipap
geraniol
geranium
ginger
Glechoma hederacea
glyceryl monolaurate
Glycolic acid
Gnaphalium
goldenseal
gooseberry
gotu kola
grape
Greek mountain tea
green tea
Guava
gum
Helicteres isora
Horsemint
Indian bael
Indian coraltree
Indian fagonia
Indian frankincense
iridoid glycosides
iridoids
Isatis
isoquinoline alkaloids
Kefir
Kokilaksha
labrador tea
lactiplantibacillus plantarum
Lactobacillus casei
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus salivarius
Lactoferrin
Lactoperoxidase
Laggera pterodonta
lauric acid
lemon
Lesser speargrass
licorice root
liverwort
Loranthus
Lysimachia
lysozyme
Macaranga indica
mallow
mangostin
Matapalo Tree
melaleuca alternifolia
Menthol oil
Microbial enzymes (proprietary)
Monolaurin
Morinda
Moringa
Mustard
mustard seed
Myrobalan
Myrrh
Naphthoquinones
Nimbidin
Oligomeric proanthocyanidins
onion
Onosma bracteatum
orange
oregano
oregon grape
Orris
pagoda tree
parsley
paw paw
Pentacyclic triterpenoids
peony
Pepper Bark Tree
Peppermint
Persimmon
Phaeophyceae
Phellodendron
phellodendron amurense
phlorotannins
Phosphate ascorbate
Physalis angulata
Pimpinella
Piper nigrum
Plectranthus amboinicus
polyphenols
Portulaca
proanthocyanidins
probiotics
procyanidin
procyanidol
Propolis
punicalagins
Pycnogenol
quercetin
Quisqualis
raspberry
Rhus coriaria
rosmarinic acid
Rubus
rutin
sage
Sagebrush
Salvia
schizonepeta
Self-Heal
Sensitive Plant
Sichuan Lovage
Slippery Elm
slippery elm bark
Solanum indicum
Sophora
specialized pro-resolving mediators (SPMs)
Spilanthes
Stereospermum
Streptococcus oralis
Streptococcus salivarius
streptococcus thermophilus
Sumac
sweet flag
Sword Bean
Tamaricaceae
Tamarind
Tannins
Tea Tree Oil
Terminalia
Thaumatococcus daniellii
Thiosulfinate
Thymol
trace minerals
Trichosanthes
Triphala
Tulbaghia
turmeric
typhonium
Viola
Violet
vitamin C
vitamin E
Water Pepper
White oak
White Tea
Winter Begonia
Wulinshen
Yellow-Fruit Nightshade
Yerba buena
zanthoxylum
Zedoary
Zinc
Zingiberene
Zucchini
Other health conditions supported by Piper nigrum
Abdominal PainAcid Indigestion
Appetite (deficient)
Arthritis
Asthma
Athletic and Exercise Aids
Backache
Belching
Bronchitis
Cancer (natural therapy for)
Cancer (prevention)
Canker Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Congestion (bronchial)
Congestion (lungs)
Congestion (sinus)
Constipation (children)
Cuts
Depression
Diabetes
Digestion (poor)
Fatigue
Fever
Gingivitis
Headache (general)
Headache (sinus)
