Evidence supporting the use of: Rutin
For the health condition: Gingivitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rutin, a flavonoid glycoside found in various plants such as buckwheat, citrus fruits, and apples, has been investigated for its potential benefits in oral health, particularly in managing gingivitis. Scientific interest in rutin for gingivitis stems from its antioxidant, anti-inflammatory, and vasoprotective properties. A few laboratory studies and small-scale clinical trials have indicated that rutin may reduce oxidative stress and inflammation in gingival tissues, which are key pathological features of gingivitis. For example, rutin has been shown in vitro to inhibit the production of pro-inflammatory cytokines and to scavenge reactive oxygen species, which are elevated in periodontal disease. Limited animal studies also suggest that rutin can attenuate periodontal tissue destruction in experimentally induced periodontitis. However, robust clinical evidence in humans is lacking. Only a handful of preliminary studies have evaluated the effects of topical or systemic rutin on gingival inflammation, and while some have reported modest improvements in gingival indices, these studies often suffer from small sample sizes and methodological limitations. As a result, while there is a plausible scientific rationale for rutin’s use in gingivitis, and some early-stage evidence, the overall quality and quantity of data supporting its efficacy remains low. Therefore, further well-designed human clinical trials are needed before rutin can be conclusively recommended as an adjunctive treatment for gingivitis in clinical practice.

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