Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the health condition: Gingivitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Superoxide dismutase (SOD) is an endogenous antioxidant enzyme that plays a critical role in neutralizing superoxide radicals, thereby protecting tissues from oxidative stress. In the context of gingivitis, research has demonstrated that oxidative stress and reactive oxygen species (ROS) contribute significantly to the inflammation and tissue destruction characteristic of periodontal diseases. Several studies have found that patients with gingivitis and periodontitis have lower levels of SOD in their gingival crevicular fluid and saliva, suggesting a link between antioxidant defense and periodontal health.

Experimental and clinical studies have evaluated the potential benefit of SOD supplementation or topical application in managing gingival inflammation. Some randomized controlled trials and in vitro studies have reported that boosting SOD activity, either through direct application or by using SOD-mimetic compounds, can reduce markers of oxidative stress and inflammation in gingival tissues. These effects are generally attributed to SOD’s capacity to limit ROS-induced damage, thereby helping to control the inflammatory process.

However, the clinical evidence remains moderate, with variability in study designs, sample sizes, and delivery methods (topical vs. systemic). While the mechanistic rationale is strong and preliminary results are promising, larger and more rigorous clinical trials are needed to fully establish the efficacy and optimal use of SOD for gingivitis. As a result, SOD’s use in this context is scientifically justified, but the overall strength of evidence is moderate rather than definitive.

More about SOD (Superoxide Dismutase, antioxidant activity)
More about Gingivitis

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ajoene
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myrobalan
betel
bifidobacterium bifidum
bifidobacterium longum
bio ecolian (proprietary)
bisabolol
black garlic
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black walnut
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cat's claw
catechins
chamomile
cinnamon
citrus bioflavonoids
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coconut milk
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turmeric
epigallocatechin gallate (EGCG)
flavonols
ginger
goldenseal
gooseberry
gotu kola
grape
greek mountain tea
onion
green tea
lactobacillus casei
lactobacillus gasseri
lactobacillus lactis
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus salivarius
lactoferrin
lactoperoxidase
lauric acid
lemon
licorice root
microbial enzymes (proprietary)
monolaurin
moringa
mustard seed
orange
oregano
oregon grape
parsley
peppermint oil
phellodendron amurense
quercetin
raspberry
rutin
sage
schizonepeta
slippery elm bark
specialized pro-resolving mediators (SPMs)
streptococcus thermophilus
triphala
vitamin C
vitamin E
xylitol
zinc
bentonite
typhonium
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ferula assafoetida
commiphora
blackboard tree
caesalpinia crista
bee pollen
peony
myrrh
sweet flag
morinda
trichosanthes
zanthoxylum
polyphenols
trace minerals
fulvic acid
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Bacteria
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benzyl isothiocyanate
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coconut oil
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Products containing SOD (Superoxide Dismutase, antioxidant activity)

We currently have no products on Vitabase that contain this ingredient.