Polygonatum, commonly known as Solomon's Seal, has a long history of use in traditional herbal medicine, particularly within Traditional Chinese Medicine (TCM) and some Western herbal practices. In TCM, Polygonatum species (notably Polygonatum sibiricum and Polygonatum odoratum) are considered to have nourishing and moistening properties, and are sometimes used as "tonics" for various conditions involving weakness or deficiency. There are anecdotal and traditional reports suggesting its use for supporting the body's response to swollen glands, including lymph nodes, although this is not a primary or well-documented indication in most traditional texts.

The rationale for use in swollen glands is largely based on the herb's reputed ability to "harmonize" or "tonify" fluids and tissues, potentially supporting lymphatic function indirectly. However, there is little to no clinical or scientific research specifically validating Polygonatum for swollen lymph glands or lymphatic disorders. The available evidence is mostly historical and anecdotal, with modern herbalists sometimes referencing its use for glandular swellings in eclectic or folk medicine traditions.

Overall, Polygonatum's use for swollen lymph glands is rooted in tradition rather than scientific validation, and the supporting evidence is weak, primarily limited to historical usage rather than experimental or clinical data.