Didymocarpus, particularly Didymocarpus pedicellata, has a long-standing history of use in traditional Ayurvedic medicine, primarily for urinary and renal health. Its use to support the glandular system (which includes endocrine glands) is less well-documented, but some herbal traditions have broadly linked its "balancing" effects to glandular health. The evidence for its efficacy in this context is primarily traditional, relying on historical formulations and anecdotal use rather than rigorous scientific research.

The most notable references to Didymocarpus in classical texts are for its use in polyherbal preparations like "Cystone," which is marketed for kidney and urinary tract health. Claims regarding its benefits for the glandular system are extrapolated from its anti-inflammatory and diuretic properties, and its role in reducing oxidative stress, but these claims lack direct research involving endocrine or other glandular tissues. There are a few in vitro and animal studies suggesting antioxidant activity, but no clinical trials or modern pharmacological studies specifically investigating effects on the glandular system.

In summary, the use of Didymocarpus for supporting the glandular system is primarily based on tradition and indirect reasoning rather than robust scientific validation. The evidence base is limited, and any claims should be interpreted with caution until further research is available.