Evidence supporting the use of: Gamma-linolenic acid
For the body system: Glandular System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in plant oils such as evening primrose oil, borage oil, and black currant seed oil. Its use to support the glandular system, particularly for hormonal balance and inflammatory modulation, has some scientific foundation. GLA is a precursor to dihomo-gamma-linolenic acid (DGLA), which can be further metabolized to anti-inflammatory eicosanoids. There is moderate evidence that GLA supplementation can alleviate symptoms of certain glandular and endocrine-related conditions, such as premenstrual syndrome (PMS), mastalgia (breast pain), and, to a lesser extent, menopausal symptoms. Some studies have shown improvement in PMS symptoms and breast tenderness, possibly through GLA’s influence on prostaglandin synthesis and hormonal regulation. However, results are mixed, with some trials reporting minimal benefit. The evidence for GLA’s role in other glandular or endocrine disorders (such as thyroid or adrenal function) is sparse and less convincing. Overall, while GLA is not a panacea for all glandular issues, there is a reasonable scientific rationale and moderate clinical evidence supporting its use for specific hormonal and inflammatory conditions related to the glandular system.

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Products containing Gamma-linolenic acid

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