Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Glycyrrhizin, a major active compound in licorice root (Glycyrrhiza glabra), has a long history of use in traditional medicine systems, particularly in Traditional Chinese Medicine (TCM) and Ayurveda, for its purported benefits to the glandular system—especially the adrenal glands. In TCM, licorice is considered a harmonizing herb and is believed to support the body’s stress response and endocrine balance. Traditional use often involves supporting adrenal function in cases of fatigue or weakness, which are considered manifestations of glandular imbalance.

While there is some scientific research indicating that glycyrrhizin can influence cortisol metabolism by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase, thus increasing cortisol availability, direct clinical evidence for its efficacy in supporting the overall glandular system in humans is limited. Most modern evidence focuses on glycyrrhizin’s anti-inflammatory and antiviral properties, rather than direct glandular support. Furthermore, long-term or excessive consumption can disrupt electrolyte balance and lead to pseudoaldosteronism, a condition mimicking excess aldosterone (a hormone produced by the adrenal glands). Thus, while traditional use is well-established, scientific validation for glandular system support is not robust.

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Other body systems supported by Glycyrrhizin

Adrenal Cortex
Adrenal Glands
Bronchials
Cortisol
Digestive System
Gastrointestinal Tract
Glandular System
Hepatic System
Immune System
Intestinal System
Liver
Lungs
Mucus Membranes
Respiratory System
Small Intestines
Spleen
Stomach

Products containing Glycyrrhizin

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