Leptadenia (Leptadenia reticulata) has a long history of use in traditional medicine systems, particularly in Ayurveda, where it is known as "Jivanti." Traditional Ayurvedic texts describe Leptadenia as a rejuvenating herb, often classified as a "Rasayana," which is believed to support vitality and overall bodily functions, including the glandular system. Its use for promoting lactation, enhancing stamina, and supporting reproductive health has been documented in classical texts, suggesting a broad role in supporting various endocrine glands.

However, while Leptadenia is traditionally believed to nourish and support glandular health, there is a lack of robust scientific studies directly linking Leptadenia to measurable improvements in glandular system function in humans. Some preliminary animal studies have hinted at immunomodulatory, galactagogue (milk-producing), and adaptogenic effects, but these are not sufficient for strong scientific validation. There are also phytochemical analyses showing the presence of alkaloids, flavonoids, and other constituents that could have physiological effects, but the evidence does not firmly establish its efficacy for glandular system support.

In summary, the use of Leptadenia to support the glandular system is primarily justified by traditional use rather than modern scientific evidence. The evidence rating remains modest, as clinical validation is lacking.