Mandrake (Mandragora officinarum) has a long history of use in traditional herbal medicine, especially within European and Middle Eastern folk practices. Historically, the plant’s roots have been associated with various mystical and medicinal properties, including use as an aphrodisiac, anesthetic, and for purported benefits to reproductive and glandular health. In the context of the glandular system, mandrake was sometimes used in traditional remedies to influence hormonal balance, fertility, or sexual function, although these uses were based more on folklore and the plant’s anthropomorphic root shape than on empirical evidence.

From a scientific perspective, there is limited to no clinical research validating mandrake’s efficacy for supporting the glandular system. The plant’s alkaloids (notably hyoscyamine and scopolamine) have known pharmacological effects, particularly as anticholinergics, but these effects are not specific or supportive to the glandular system in a therapeutic sense and can be toxic. Modern herbal and medical literature generally does not recommend mandrake for glandular health, and its safety profile is a concern due to risks of toxicity and side effects. Thus, while its use is rooted in tradition, the evidence supporting its benefits for the glandular system is weak.