Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Pregnenolone is a naturally occurring steroid hormone and precursor in the biosynthesis of many other steroid hormones, including progesterone, cortisol, and the sex hormones. Its use as a supplement to support the Glandular System—which comprises endocrine glands such as the adrenal, pituitary, and thyroid glands—is primarily based on traditional and theoretical rationale. Historically, pregnenolone was studied in the 1940s for potential benefits related to fatigue and arthritis, but widespread use declined once corticosteroids became available. The idea behind its supplementation is that, by providing a precursor, the body may better regulate hormone production and support overall glandular health. However, direct scientific evidence supporting pregnenolone's efficacy in maintaining or restoring glandular system function is limited. Some small studies and anecdotal reports suggest potential benefits for mood, memory, and stress response, largely attributed to its role in neurosteroid and hormone synthesis, but robust clinical data are lacking. As of now, there is insufficient scientific validation to support its use specifically for glandular system health, and its use remains more traditional or theoretical than evidence-based.

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Other ingredients that support Glandular System

Other body systems supported by pregnenolone

Products containing pregnenolone

Douglas Laboratories DHEA Plus
Pure Encapsulations Pregnenolone 10 mg
Pure Encapsulations Pregnenolone 10 mg
Douglas Laboratories Pregnenolone 25 mg
Douglas Laboratories Pregnenolone 25 mg
Pure Encapsulations Pregnenolone 30 mg
Pure Encapsulations Pregnenolone 30 mg
Douglas Laboratories Pregnenolone 5 mg
Designs For Health Pregnenolone CRT™