Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenium is an essential trace mineral that plays a critical role in various bodily functions, particularly in the health of the glandular (endocrine) system. Its most well-established scientific connection is with thyroid gland function. Selenium is a cofactor for the enzymes known as iodothyronine deiodinases, which are responsible for the activation and deactivation of thyroid hormones. Adequate selenium status supports the synthesis and metabolism of thyroid hormones, which are essential for regulating metabolism, growth, and development. Several studies have indicated that selenium supplementation can benefit individuals with autoimmune thyroiditis (such as Hashimoto’s thyroiditis), potentially reducing thyroid antibody levels and improving subjective well-being, although findings are mixed and not all studies show benefit. Additionally, selenium is a component of antioxidant enzymes such as glutathione peroxidases, which protect glandular tissue from oxidative damage. Selenium deficiency is associated with impaired immune function and increased risk of thyroid dysfunction, further underscoring its importance in glandular system support. However, while there is good evidence for selenium’s role in thyroid health (a key glandular organ), broader support for all glands in the endocrine system is less well-established. Most scientific research focuses specifically on the thyroid rather than the entire glandular system.

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