Evidence supporting the use of: Withanolides
For the body system: Glandular System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Withanolides are a group of naturally occurring steroidal lactones primarily found in the plant Withania somnifera, commonly known as Ashwagandha. Ashwagandha has a long history of use in traditional Ayurvedic medicine as a tonic for enhancing vitality, managing stress, and supporting overall endocrine (glandular) health. Recent scientific investigations have begun to elucidate the mechanisms by which withanolides may support the glandular system, particularly the adrenal and thyroid glands.

Preclinical and some clinical studies suggest that withanolides may modulate the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in the body’s response to stress. Research indicates that Ashwagandha extracts standardized for withanolides can reduce serum cortisol levels, indicating a potential adaptogenic effect—helping the body adapt to stress and support adrenal health. Some studies have also reported improvements in thyroid function (notably increased T3 and T4 hormone levels) in individuals with subclinical hypothyroidism.

While the evidence base is growing, most clinical studies to date are small and often use Ashwagandha root extract rather than isolated withanolides, making it difficult to attribute effects solely to withanolides. Nonetheless, the current scientific literature provides moderate support for the role of withanolides in supporting the glandular system, particularly concerning stress adaptation and thyroid function. More robust, large-scale human trials are needed to confirm these benefits.

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amino acids
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fruit and vegetable blend (proprietary)
gamma linolenic acid (GLA)
garlic bulb
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niacin (vitamin B3)
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Products containing Withanolides

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