Evidence supporting the use of: Superoxide Dismutase
For the health condition: Glaucoma

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide Dismutase (SOD) is an enzyme that plays a crucial role in protecting cells from oxidative stress by catalyzing the dismutation of superoxide radicals into oxygen and hydrogen peroxide. Oxidative stress has been implicated in the pathogenesis of glaucoma, particularly in the damage to retinal ganglion cells and the optic nerve. Several experimental and preclinical studies have investigated the potential neuroprotective effects of SOD or SOD-mimetics in the context of glaucoma. These studies suggest that enhancing SOD activity may reduce oxidative damage and cell death in animal models of glaucoma. For example, topical or systemic administration of SOD or its mimetics has been shown to mitigate retinal ganglion cell loss in some preclinical studies.

However, clinical evidence in humans remains limited and inconclusive. There are few well-designed, large-scale clinical trials evaluating the efficacy of SOD supplementation or therapy in glaucoma patients. Some small studies and pilot trials have reported modest benefits in reducing markers of oxidative stress, but consistent clinical improvements in vision or disease progression have not been robustly demonstrated. Therefore, while there is a scientific rationale for the use of SOD based on its antioxidant properties and preclinical data, the current level of evidence supporting its efficacy in treating or supporting glaucoma is weak (hence the rating of 2/5). More rigorous human studies are needed to establish SOD's therapeutic value in glaucoma.

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