Evidence supporting the use of: Ursane-type triterpenoid
For the health condition: Gout

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursane-type triterpenoids, such as ursolic acid, are compounds found in many medicinal plants. Their use in supporting or treating gout is primarily based on emerging scientific evidence rather than long-standing traditional use. Preclinical studies have shown that ursane-type triterpenoids possess anti-inflammatory and antioxidant properties, which are relevant to the pathophysiology of gout—a condition characterized by acute inflammation due to monosodium urate crystal deposition in joints.

Several in vitro and animal studies have demonstrated that ursolic acid can inhibit pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and reduce the activity of enzymes like xanthine oxidase, which is involved in uric acid production. For example, a 2016 study published in "Phytomedicine" found that ursolic acid reduced uric acid levels and inflammation markers in gout-induced mice. However, direct clinical evidence in humans is very limited or absent.

In summary, while ursane-type triterpenoids have demonstrated mechanisms that could theoretically benefit gout sufferers, the evidence remains at a preclinical stage. There is presently insufficient clinical data to robustly support their use for treating or preventing gout in humans. More research, especially randomized controlled trials, is needed to establish efficacy and safety for this indication.

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