Relationship: Grave's Disease and vitamin D

Evidence supporting the use of: Vitamin D
For the health condition: Grave's Disease

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Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has gained attention in recent years for its potential role in supporting autoimmune diseases, including Graves' Disease, which is an autoimmune hyperthyroidism. Several studies have found that patients with Graves' Disease are more likely to have vitamin D deficiency compared to healthy controls. Low vitamin D status has been associated with increased risk and severity of several autoimmune conditions, suggesting a possible immunomodulatory effect of vitamin D.

Mechanistically, vitamin D is thought to influence the immune system by modulating T-cell responses and promoting immune tolerance, potentially reducing autoimmune attack on the thyroid gland. However, while observational studies consistently report lower vitamin D levels in Graves’ patients, interventional studies are limited. A few small trials suggest that vitamin D supplementation may improve some markers of thyroid function or autoimmunity, but these effects are generally modest and not consistently replicated.

Current major endocrinology guidelines do not recommend vitamin D as a primary treatment for Graves’ Disease, but they do recommend correcting deficiency, which is common in the general population and may be more frequent in those with thyroid disease. Therefore, vitamin D is used adjunctively, mainly to address deficiency and possibly support immune health, rather than as a direct treatment for Graves’ Disease itself. The scientific evidence for its use specifically in Graves’ is still emerging and not robust, justifying a modest rating on the evidence scale.

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Evidence supporting the use of: Vitamin D
For the health condition: Grave's Disease

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Health Concerns

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Evidence supporting the use of: Vitamin DFor the health condition: Grave's Disease

Table of Contents

Synopsis

Other ingredients used for Grave's Disease

Other health conditions supported by vitamin D

Products containing vitamin D

Evidence supporting the use of: Vitamin D
For the health condition: Grave's Disease