Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D (cholecalciferol) is not a primary treatment for Grave's Disease, which is an autoimmune hyperthyroidism. However, its use is supported by a modest amount of scientific evidence relating to immune modulation and bone health in this context. Multiple studies have found that individuals with autoimmune thyroid diseases, including Grave's Disease, often have lower serum vitamin D levels compared to healthy controls. Vitamin D is recognized for its role in modulating the immune system, particularly in the balance between Th1 and Th2 lymphocytes, which are involved in autoimmunity. Some research suggests that vitamin D deficiency may be associated with increased risk or severity of autoimmune thyroid diseases, but causation has not been firmly established.

Additionally, Grave's Disease and its treatments (such as antithyroid drugs or radioactive iodine) can increase the risk of osteoporosis and fractures due to accelerated bone turnover associated with hyperthyroidism. Vitamin D supplementation is often recommended alongside calcium to support bone health in these patients, as part of standard osteoporosis prevention guidelines, not as a direct treatment for Grave's Disease itself.

Overall, while there is some scientific rationale and observational evidence for checking and correcting vitamin D deficiency in Grave's Disease patients, especially for bone health, robust clinical trials directly supporting vitamin D supplementation as a means to alter the course of Grave's Disease are lacking. Thus, the evidence for its use in this context is moderate to low (rating: 2).

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