Evidence supporting the use of: Citrus bioflavonoids
For the body system: Gums

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrus bioflavonoids are plant-derived compounds commonly found in citrus fruits. Their use for supporting gum (periodontal) health is primarily based on their established antioxidant and anti-inflammatory properties. Several small studies and preclinical investigations have explored their effects on gum health. Bioflavonoids, such as hesperidin and rutin, have been shown to strengthen capillaries, reduce inflammation, and potentially support collagen production—important factors for maintaining healthy gum tissue. Some clinical studies suggest that supplementation with citrus bioflavonoids, often in combination with vitamin C, may help reduce gum bleeding and improve periodontal parameters in people with gum disease, possibly due to enhanced vascular integrity and reduced oxidative stress.

However, the scientific evidence is limited and not robust. Most available studies are small, short-term, or use bioflavonoids in combination with other nutrients, making it difficult to attribute benefits solely to bioflavonoids. Systematic reviews recognize a possible adjunctive role but generally call for larger, well-designed clinical trials to confirm efficacy and clarify mechanisms. Thus, while there is a scientific rationale and some supportive evidence for using citrus bioflavonoids to support gum health, the overall strength of evidence is modest (rated 2 out of 5).

More about citrus bioflavonoids
More about Gums

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Designs For Health Electrolyte Synergy™
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Pure Encapsulations Hair/Skin/Nails Ultra
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Douglas Laboratories Malic Acid + Magnesium
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Metagenics Multigenics Intensive Care
Metagenics Multigenics Intensive Care without Iron
Metagenics Multigenics without Iron
Douglas Laboratories Natural C
Integrative Therapeutics Nutrivitamin No-Iron
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Primal Multi™
Pure Encapsulations PurePals
Pure Encapsulations PurePals with Iron
Vitabase Quercetin Plus
Designs For Health Stellar C™
Metagenics Ultra Potent-C 1000
Metagenics Ultra Potent-C 500
Metagenics Ultra Potent-C Chewable
Metagenics Ultra Potent-C Powder
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Thorne Vitamin C With Flavonoids
Integrative Therapeutics Vitamin C with Quercetin
Metagenics Wellness Essentials Active Daily Packs