Evidence supporting the use of: Hesperidin methyl chalcone
For the body system: Gums
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Hesperidin methyl chalcone is a flavonoid derivative commonly found in citrus fruits and is sometimes included in supplements aimed at oral or vascular health. There is limited but notable scientific evidence suggesting that hesperidin and its derivatives may provide some benefit in supporting gum (periodontal) health, primarily due to their antioxidant and anti-inflammatory properties. A few small clinical studies and animal models have demonstrated that hesperidin can reduce inflammation and oxidative stress in gingival tissues, which are key factors in gum disease. For example, a 2015 randomized controlled trial found that a hesperidin-rich supplement reduced indices of gingival inflammation compared to placebo. Mechanistically, hesperidin methyl chalcone has demonstrated the ability to inhibit pro-inflammatory cytokines and reduce capillary permeability, which may help minimize gum bleeding and swelling.
However, the evidence base is still modest, with most studies having small sample sizes or being conducted in animals rather than in large, well-controlled human populations. The ingredient is primarily used in combination with other compounds rather than as a standalone therapy for gum health. Clinical guidelines do not currently recommend hesperidin methyl chalcone specifically for periodontal disease, but its inclusion in some oral health supplements can be traced to its general anti-inflammatory and vasoprotective effects. Overall, while there is some scientific rationale and preliminary evidence supporting its use for gums, it is not yet strongly validated or universally endorsed for this purpose.
Other ingredients that support Gums
cutchallspice
aloe vera
anthocyanins
apple
bayberry
beeswax
myrobalan
betel
bilberry
bisabolol
blackberry
Indian frankincense
bovine gelatin
catechins
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
collagen
turmeric
curcumin
flavonols
gelatin
goldenseal
goldenseal
gooseberry
gum ghatti
hesperidin
horsetail
hyaluronic acid
lactobacillus reuteri
lactobacillus salivarius
lactoperoxidase
lemon
licorice root
mango
marshmallow
mastic gum
mixed carotenoids
omega-3 fatty acids
orange
oregon grape
phenolic acids
pine bark
plantain
raspberry
rose hips
sage
slippery elm bark
triphala
vitamin C
vitamin K
white willow
xanthan gum
xylitol
zinc
yellow root
cardamom
capsicum
neem tree
pterocarpus marsupium
commiphora
yarrow
prickly ash
myrrh
zanthoxylum
polyphenols
menthol oil
shepherd's purse
white oak
herbal blend (proprietary)
melaleuca alternifolia
cayenne pepper
Avens
Apple Cider Vinegar
Asiaticoside
acacia
Agrimony
Allicin
Alchemilla
Aucubin
Ascophyllum nodosum
Areca
Agonandra
Agrimonia pilosa
Alkanna
Bee Propolis
Betony
Bai Ji
Balsam
Bistort
Baccharis dracunculifolia
Brazillian peppertree
Bloodroot
Benzoin
berry
Boswellia
Bletilla
Bioflavonoids
Bee products
Comfrey
Calendula
Carvacrol
Cinquefoil
Curcuminoid
Citrus
Cajuput
Canaigre
Catechu
Coca
Cistus
Curcuma
Cranesbill
Cyanthillium cinereum
Collinsonia
Casearia sylvestris
Calycophyllum
Drynaria
Dragon's Blood
Echinacea
Emblicanin
European-Five Finger Grass
Eugenol
Fiber
Flavonoids
Fluoride
Fructoborate
Flavanones
Fluorine
Fleabane
Flavans
Frankincense
Flavonones
Goldthread
Guava
Gambir
Garlic
Glechoma hederacea
Mallow
Oak
Other body systems supported by Hesperidin methyl chalcone
ArteriesCapillaries
Circulatory System
Gums
Veins