Hyaluronic acid (HA) has some scientific support for its use in supporting gum (periodontal) health. HA is a naturally occurring glycosaminoglycan found in connective tissues, including those within the oral cavity. Its high biocompatibility and ability to retain moisture have made it a focus of research in periodontal therapy. Several clinical studies and reviews have investigated the adjunctive use of topical or injectable hyaluronic acid in the treatment of gingivitis and periodontitis. Evidence suggests that HA may help reduce inflammation, promote wound healing, and support tissue regeneration in periodontal tissues.

For example, a 2016 systematic review (J Clin Periodontol, 2016) concluded that adjunctive application of HA in periodontal therapy showed some benefit in reducing pocket depth and improving clinical attachment levels, although the effect size was modest and further high-quality studies were recommended. The proposed mechanisms include HA’s anti-inflammatory properties, its ability to modulate the immune response, and its role in cell proliferation and migration during tissue repair. HA gels and rinses are available commercially and sometimes recommended by dental professionals as part of periodontal treatment protocols.

While the evidence is not overwhelming and HA is not a standalone treatment, there is moderate scientific validation for its supportive role in managing gum health, particularly as an adjunct to standard care.