Evidence supporting the use of: Proanthocyanidin (unspecified)
For the body system: Gums

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins are a class of polyphenolic compounds found in many plants, notably in grape seeds, cranberries, and pine bark. There is a growing body of scientific evidence suggesting that proanthocyanidins can support gum (periodontal) health. Their primary mechanism is attributed to potent antioxidant and anti-inflammatory properties, which can reduce oxidative stress and inflammation in gum tissues. Several in vitro and animal studies have demonstrated that proanthocyanidins inhibit the growth of oral pathogens, such as Porphyromonas gingivalis, a key bacterium in gum disease. Additionally, proanthocyanidins have been shown to prevent the adhesion of bacteria to oral surfaces, thereby reducing plaque formation and the risk of periodontal disease.

Clinical research, while limited, is emerging. Some small human studies report improved periodontal outcomes (such as reduced gingival bleeding and plaque indices) after supplementation with proanthocyanidin-rich extracts (e.g., from cranberries or grape seed). However, larger and more robust human trials are needed to confirm these findings and to establish optimal dosing and long-term safety. Overall, the current scientific evidence supports the use of proanthocyanidins as an adjunct to conventional oral hygiene for gum health, but does not yet rise to the level of definitive proof.

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