Evidence supporting the use of: Vitamin C (calcium ascorbate)
For the body system: Gums

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin C, also known as ascorbic acid (including its mineral salt form, calcium ascorbate), has strong scientific support for its role in gum (periodontal) health. Vitamin C is essential for collagen synthesis, a key structural protein in gum tissue. Scientific studies have demonstrated that deficiency in vitamin C leads to scurvy, which is characterized by gum bleeding, swelling, and eventual tooth loss due to impaired collagen formation and increased capillary fragility. Observational and interventional studies in humans show that insufficient vitamin C intake is associated with increased risk of periodontal disease. Supplementation with vitamin C has been shown to improve gum health in deficient individuals and may reduce bleeding and inflammation.

The mechanism of action is well understood: vitamin C acts as a cofactor for prolyl and lysyl hydroxylase enzymes critical for collagen cross-linking. Additionally, its antioxidant properties help modulate inflammatory responses in periodontal tissues. While severe deficiency is rare in developed countries, marginal deficiency can still negatively impact gum health, especially in smokers and populations with poor diets. Clinical trials and reviews have concluded that adequate vitamin C intake supports periodontal health, though supplementation above recommended dietary allowances shows limited additional benefit in healthy individuals.

Calcium ascorbate is a buffered form of vitamin C that is gentler on the stomach than ascorbic acid, making it suitable for oral supplementation. Overall, the use of vitamin C (including calcium ascorbate) to support gum health is well-supported by scientific evidence.

More about Vitamin C (calcium ascorbate)
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Products containing Vitamin C (calcium ascorbate)

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