Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polypeptide complexes are mixtures of short chains of amino acids (peptides) that have been used in hair care formulations, particularly in topical products. The rationale for their use is rooted in the understanding that hair is primarily composed of keratin, a protein, and peptides may help to strengthen or repair damaged hair fibers by providing building blocks or signaling molecules that encourage keratin production or repair. Several in vitro and small clinical studies have examined the effects of specific peptides or polypeptide complexes on hair health, showing potential benefits such as improved hair strength, texture, and, in some cases, stimulation of hair follicle activity. For example, copper peptides and other bioactive peptides have been shown to have positive effects on hair growth in some studies, likely through their roles in cellular signaling and tissue repair.

However, the term "polypeptide complex (proprietary)" is non-specific, and the efficacy depends greatly on the types of peptides used, their concentrations, and delivery methods. While there is some emerging scientific support for the use of specific peptides in promoting hair health or growth, the overall quality of evidence remains moderate, with a need for larger, well-controlled human studies. Thus, while the use of polypeptide complexes in hair care is justified by preliminary scientific evidence, the strength of this evidence is currently limited.

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Products containing polypeptide complex (proprietary)

Metagenics Ceriva®