Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonols are a subgroup of flavonoids—polyphenolic compounds found abundantly in fruits, vegetables, teas, and other plant-based foods. Examples include quercetin, kaempferol, and myricetin. The rationale for their use in supporting hair health, particularly for hair loss or thinning, stems from their antioxidant and anti-inflammatory properties. Oxidative stress and inflammation are implicated in the miniaturization of hair follicles and the progression of conditions like androgenetic alopecia and telogen effluvium.

Several in vitro and animal studies suggest that flavonols can protect dermal papilla cells (crucial for hair growth) from oxidative damage and may modulate signaling pathways involved in hair follicle cycling. For instance, quercetin has been shown in animal studies to promote hair growth and inhibit factors that trigger hair follicle regression. However, robust clinical evidence in humans remains limited. Few small-scale human studies or clinical trials have directly assessed the efficacy of flavonol supplementation for hair loss, and results have been inconsistent or preliminary.

Therefore, while there is some scientific rationale and preclinical evidence supporting the use of flavonols for hair health, the current level of direct, high-quality clinical evidence is low. Most recommendations are extrapolated from broader research on the antioxidant benefits of flavonols, rather than conclusive human trials on hair loss or thinning.

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Products containing flavonols

Douglas Laboratories Ultra Preventive 50+ -EZ Swallow