Vitamin E, particularly in its alpha-tocopherol and tocotrienol forms, has been explored for its potential role in supporting hair health, including hair loss and thinning. Alpha-tocomonoenol is a less common form of Vitamin E, structurally related to tocopherols and tocotrienols, but the majority of clinical research focuses on alpha-tocopherol and tocotrienol derivatives.

Scientific evidence for the use of Vitamin E in hair loss is limited but present. Some studies suggest that Vitamin E's antioxidant properties may help reduce oxidative stress in the scalp, a factor implicated in hair follicle aging and hair loss. A small randomized controlled trial in 2010 found that tocotrienol supplementation resulted in a statistically significant increase in hair count in volunteers with hair loss compared to placebo. However, this study had a modest sample size and did not use alpha-tocomonoenol specifically.

There are also a few animal model studies and in vitro experiments that indicate potential benefits of Vitamin E derivatives in promoting hair growth and protecting hair follicle cells from oxidative damage. However, comprehensive, large-scale clinical trials are lacking, and direct evidence for alpha-tocomonoenol itself is virtually absent.

In summary, while there is some scientific basis for Vitamin E's role in supporting hair health, the evidence remains preliminary and indirect, particularly for the alpha-tocomonoenol form.