Evidence supporting the use of: Cysteine
For the health condition: Hangover

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cysteine, particularly in its N-acetylcysteine (NAC) form, has been investigated for its potential role in reducing hangover symptoms. The scientific rationale centers on cysteine's role as a precursor to glutathione, a critical antioxidant in the liver. During alcohol metabolism, the body produces acetaldehyde, a toxic intermediate that contributes to hangover symptoms. Glutathione helps neutralize acetaldehyde, and cysteine supplementation can, in theory, help replenish glutathione stores and accelerate detoxification. Some animal studies (e.g., rat models) have shown that cysteine or NAC administration can enhance acetaldehyde clearance, potentially reducing toxicity. However, human clinical evidence is limited and mixed. A few small-scale studies and surveys have evaluated products containing cysteine or NAC for hangover prevention or relief, but results are inconclusive or show modest benefits at best. A 2020 randomized controlled trial on L-cysteine supplementation in humans showed some reduction in hangover symptoms, but the sample size was small and the reduction was not dramatic. Most studies emphasize the need for further research with larger sample sizes and better controls. Overall, while there is a plausible biochemical mechanism and some preliminary scientific evidence, the strength of evidence is weak to moderate and does not firmly establish cysteine as an effective hangover remedy.

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