Evidence supporting the use of: Dihydromyricetin
For the health condition: Hangover

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dihydromyricetin (DHM), also known as ampelopsin, is a flavonoid compound extracted from the Japanese raisin tree (Hovenia dulcis). Its use for hangover relief is primarily supported by emerging scientific evidence rather than longstanding traditional use, though the source plant features in traditional Chinese medicine for detoxification. Notably, a 2012 study published in The Journal of Neuroscience demonstrated that DHM administration in rodents counteracted alcohol intoxication, reduced withdrawal symptoms, and accelerated the clearance of alcohol from the body (Shen et al., 2012). The proposed mechanisms include modulation of GABAA receptors and enhancement of alcohol metabolism by upregulating enzymes such as alcohol dehydrogenase and acetaldehyde dehydrogenase.

However, human data are limited. A few small pilot studies and anecdotal reports suggest potential benefits in reducing hangover symptoms, but robust, placebo-controlled clinical trials in humans are lacking. As such, the overall evidence supporting DHM for hangover mitigation is promising but preliminary, and further research is necessary to establish safety, efficacy, and optimal dosing in humans.

More about dihydromyricetin
More about Hangover

Other health conditions supported by dihydromyricetin

Alcoholism
Fatty Liver Disease
Hangover
Inflammation
Liver Detoxification

Products containing dihydromyricetin

We currently have no products on Vitabase that contain this ingredient.