Evidence supporting the use of: Cannabidiol
For the health condition: Headache (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabidiol (CBD), a non-psychoactive component of the cannabis plant, has garnered interest for its potential to support or treat headaches, including migraines and general headache disorders. While CBD has a long history of use in traditional medicine for a variety of ailments, its direct application specifically for headaches is primarily supported by emerging scientific evidence rather than a deep-rooted traditional use for this indication.

Preclinical studies suggest that CBD may exert analgesic and anti-inflammatory effects by interacting with the endocannabinoid system, modulating serotonin receptors, and reducing neuroinflammation. These mechanisms could theoretically contribute to headache relief. However, robust clinical trials directly assessing the efficacy of CBD for headache management are limited. Some small studies and case reports have described potential benefits, particularly for migraine sufferers, but results are inconsistent and often confounded by the use of preparations containing both CBD and THC (tetrahydrocannabinol).

Current systematic reviews and consensus statements from headache specialists generally conclude that evidence supporting CBD's use for headaches is insufficient and more high-quality, placebo-controlled studies are needed. Thus, while there is a plausible scientific rationale and preliminary data suggesting possible benefit, the strength of the evidence is low (rated 2 out of 5), and CBD cannot be considered a first-line or well-established treatment for headache disorders at this time.

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Other ingredients used for Headache (general)

1,3,7-Trimethylpurine-2,6-dione
Abrus
Achyranthes
Aconite
Aerva lanata
Agarwood
Agastache
Agrimonia pilosa
Agrimony
Ajuga
Albizia
alpha-pinene
alpha-terpineol
alpinia galangal
Alstonia scholaris
amber
ambergris
American Liverleaf
Amor seco
Anemone
Angelica
anise
apple
apple cider vinegar
Arani
Ardisia
Arisaema
asafoetida
Asam gelugor
Asarum heterotropoides
ashwagandha
aster root
atractylone
avens
Baccharoides anthelmintica
bael
balloon flower
balsam
bamboo
banyan
Barleria
basil
Bassia scoparia
bayleaf
Bergenia
betel
betony
birch
bitter grass
black cumin
Black Hellebore
black nightshade
black root
black salt
black seed
black tea
Black willow
blackboard tree
blackthorn
Blepharis
blue flag
Bombax
Borassus aethiopum
borassus palm
borneol
Boswellia
bottle gourd
Broussonetia
Bryonia
Buddha\'s hand
burdock
Butea monosperma
cactus
Caesalpinia crista
calamus
Camellia sinensis
camphor oil
Campylandra fimbriata
cannabidiol
Cannabis sativa oil
capsicum
cardamom
carry me seed
Carthamus
cayenne pepper
Celosia
Centipeda
Chaenomeles lagenaria
chamomile
chinatree
Chinese silkvine
chrysanthemum
Cinnamomum
cinquefoil
citron
Clary sage
Clerodendrum indicum
Clerodendrum indicum
Clerodendrum phlomidis
Clerodendrum trichotomum
coca
cola nut
colocynth
commiphora
coriander
corktree
Corydalis
costus
cucumber
Cymbopogon martini
Cynodon dactylon
Dichrostachys glomerata
divi-divi
dragonhead
elephant\'s head
Embelia
English horsemint
Erodium cicutarium
Erythropalum scandens
eugenol
European Elder
Evodia
fang-feng
fennel
fern
fernbush
ferula assafoetida
feverfew
Ficus religiosa
Ficus simplicissima
flowering quince
Flueggea suffruticosa
Fumaria parviflora
Galangal
ganoderma
garden cress
Gardenia jasminoides
Gelsemium
geranium
giant blazingstar
ginger
ginseng
Glechoma hederacea
Gnaphalium
Golden Willow
goldthread
gooseberry
gotu kola
Greek mountain tea
green chiretta
green tea
Guaranine
Guava
guayusa
Heartsease
Hedychium spicatum
Hellebore
Hempnettle
henna
Herb Robert
Homalomena
Horsemint
Indian bael
Indian coraltree
Indian fagonia
Indian frankincense
Indian nightshade
indigo leaves
iridoids
Javanese Long Pepper
joe-pye
jujube
Kokilaksha
kola nut
kudzu
Kukicha
labrador tea
Large-leaved linden
Lavandin
lavender
Ledebouriella
lemon
lemon balm
Lesser speargrass
lichen
licorice root
ligustilides
Lilium polyphyllum
linalool
linden
Lindera
Litsea
little ironweed
Lophira lanceolata
Loranthus
lotus
lovage
luffa
Lycopodium
Lysimachia
Macaranga indica
mace
magnesium
mallow
Malva sylvestris
Marjoram
Matapalo Tree
Meadow sage
Meadowsweet
Mentha haplocalyx
Menthol oil
Mesua
Methylxanthine
Mezoneuron benthamianum
Microtea debilis
Milkweed
Mint
Momordica
Morinda
Moringa
Morus
Mountain Pepper
Mountain pride
Mustard
mustard seed
Myrrh
Nardostachys
Natsudaidai
Nymphaea nouchali
onion
Onosma bracteatum
orchid
Oroxylum indicum
Osha
Osmanthus
paeoniflorin
pagoda tree
Palmitoylethanolamide (PEA)
Patchouli oil
Patrinia
paw paw
peony
Peppermint
Petasines
Phellodendron
phellodendron amurense
Pimpinella
Piper chaba
Piper nigrum
Piper retrofractum
Plectranthus amboinicus
Pluchea
Polygonum
poppy
Portulaca
Premna
prepared aconite tuber
Prickly Pear Cactus
Prunus
Pulsatilla
punarnava
purple butterbur root
quail egg
riboflavin (vitamin B2)
robusta coffee
root tuber
rose
rose oil
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
Rubus
rue
sage
Sagebrush
Salicin
Salvia
Sandalwood
Sassafras
Scabrous Gentian
schizonepeta
Scoparia dulcis
scrophularia root
Self-Heal
Semecarpus anacardium
Sensitive Plant
Sida cordifolia
silk tree
Snakeroot
Solanum indicum
Sophora
soursop
Southernwood
Spanish Needle
spearmint leaf
Speedwell
Spikenard
Stachytarpheta cayennensis
Stephania root
Stereospermum
Storax
Sumac
Sweet Bay
Sweet Orange alcohol
sweetgums
Sword Bean
Szechuan lovage
Tamarind
Terminalia
Tetrahydropalmatine
Tinospora cordifolia
Triphala
Tulbaghia
turmeric
Verbena
Vervain
Vetiver
Viburnum
Violet
Water Pepper
Waterhyssop
Watermelon
Wax Gourd
white willow
Willow
Willow Bracket
Winter Begonia
Winter Savory
Wintergreen
Wood betony
Wulinshen
Xanthine
Xanthophyll
Yellow-Fruit Nightshade
Yerba buena
Yerba mate
Yuzu
zhejiang fritillary
Zingerone
Zucchini

Products containing cannabidiol

We currently have no products on Vitabase that contain this ingredient.