Clerodendrum indicum (note the correct spelling) is mainly used in traditional medicine for headache relief. In Ayurveda and other traditional practices across South and Southeast Asia, various parts of the plant, particularly the roots and leaves, are used in decoctions or pastes to manage headaches, migraines, and neuralgia. These uses are described in ethnobotanical surveys and regional pharmacopeias, reflecting the plant's place in folk remedies.

Despite this traditional use, there is a lack of robust scientific evidence or clinical trials directly demonstrating efficacy for headache treatment. Some phytochemical studies indicate the presence of flavonoids, saponins, and other bioactive compounds in Clerodendrum indicum that may have anti-inflammatory or analgesic effects, which could theoretically support its use for pain relief. However, these findings are preliminary, mostly based on in vitro or animal studies for general anti-inflammatory activity, not specifically for headaches.

In summary, the use of Clerodendrum indicum for headache is supported by traditional knowledge and ethnomedicinal reports, but scientific validation is currently minimal. More rigorous research, including clinical trials, is needed to confirm its efficacy and safety for this indication.