Evidence supporting the use of: Phthalide
For the health condition: Headache (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Phthalide, a class of compounds most notably found in plants like Ligusticum chuanxiong (Szechuan lovage) and celery, has a long-standing history in traditional Chinese medicine (TCM) for the treatment of headaches, particularly those associated with blood stasis and wind syndromes. One of the most studied phthalides is ligustilide, which is considered the major bioactive component in Chuanxiong. TCM practitioners have used Chuanxiong-containing formulas for centuries to manage headaches and migraines, often in conjunction with other herbs.

From a scientific perspective, there is limited but emerging evidence suggesting that phthalides may exert vasodilatory, anti-inflammatory, and neuroprotective effects, which could theoretically be beneficial for headache relief. Some laboratory and animal studies indicate that ligustilide can relax vascular smooth muscle and inhibit neurogenic inflammation, both of which are implicated in headache pathophysiology. However, clinical trials in humans are sparse, and the efficacy of isolated phthalide compounds for headache relief has not been conclusively demonstrated.

In summary, the use of phthalide for headache relief is primarily justified by traditional use, especially within the context of herbal remedies in East Asian medicine. The scientific evidence base is limited and does not yet provide strong support for its use as a primary treatment for headaches.

More about Phthalide
More about Headache (general)

Other ingredients used for Headache (general)

alpha-pinene
green chiretta
apple
ashwagandha
waterhyssop
bamboo
basil
betel
black cumin
black tea
Indian frankincense
burdock
cannabis sativa oil
chamomile
cucumber
turmeric
fennel
feverfew
ginger
ginseng
gooseberry
gotu kola
greek mountain tea
onion
green tea
guayusa
jujube
kudzu
lavender
lemon
licorice root
lovage
magnesium
mint
moringa
mustard seed
peppermint oil
phellodendron amurense
purple butterbur root
quail egg
riboflavin (vitamin B2)
rose oil
sage
schizonepeta
scrophularia root
spearmint leaf
triphala
watermelon
white willow
zhejiang fritillary
cardamom
capsicum
Indian bael
alpinia galangal
clerodendrum indicum
ferula assafoetida
hedychium spicatum
anise
punarnava
commiphora
tinospora cordifolia
blackboard tree
caesalpinia crista
fumaria parviflora
rubia cordifolia
peony
lingusticum wallichii
morus
myrrh
root tuber
silk tree
chrysanthemum
amber
flowering quince
fern
ganoderma
sweetgums
morinda
birch
wintergreen
camphor oil
menthol oil
aster root
yerba mate
wood betony
paw paw
indigo leaves
cayenne pepper
soursop
geranium
1,3,7-Trimethylpurine-2,6-dione
Avens
Apple Cider Vinegar
Agastache
Alpha-terpineol
Ambergris
Ardisia
Angelica
Agrimony
Achyranthes
Abrus
Asarum heterotropoides
Albizia
Aconite
Asafoetida
Ajuga
Aerva lanata
Agarwood
American Liverleaf
Anemone
Asam gelugor
Alsonia scholaris
Agrimonia pilosa
Acetylsalicylic acid
Amor seco
Arani
Arisaema
Atractylone
Betony
Black Seed
Blue Flag
Bryonia
Blackthorn
Broussonetia
Blepharis
Balsam
Bayleaf
Butea monosperma
Barleria
Bitter Grass
Bael
Boswellia
Baccharoides anthelmintica
Banyan
Black willow
black salt
Black Nightshade
Bombax
Borassus Palm
Buddha's Hand
Borassus aethiopum
Black root
Bassia scoparia
Black Hellebore
Balloon Flower
Bergenia
Bottle gourd
Borneol
Camellia sinensis
Chinese Silkvine
Cinnamomum
Clary sage
Clerodendrum trichotomum
Coriander
Clerodendrum phlomidis
Cactus
Cinquefoil
Citron
Carry Me Seed
Cymbopogon Martini
Coca
Campylandra fimbriata
Centipeda
Corktree
Chaenomeles lagenaria
Cannabidiol
Calamus
Chinatree
Corydalis
Cynodon dactylon
Costus
Carthamus
Colocynth
cola nut
Celosia
Clerodendrum indicum
DIVI-DIVI
Dragonhead
Dichrostachys glomerata
European Elder
Erythropalum scandens
Erodium cicutarium
English Horsemint
Elephant's Head
Embelia
Eugenol
Goldthread
Galangal
Lotus
Little ironweed
Mustard
Mallow
Orchid
Potato
Prickly Pear Cactus
Poppy
Rose
Spikenard
Snakeroot (unspecified)
Sandalwood
Sumac
Sweet Orange alcohol
Vervain
Vinegar
Zucchini

Products containing Phthalide

We currently have no products on Vitabase that contain this ingredient.