Asarum sieboldii (commonly known as wild ginger or "saishin" in traditional East Asian medicine) has been used historically in Chinese and Japanese herbal medicine to address headache, particularly those associated with sinus congestion. In Traditional Chinese Medicine (TCM), Asarum sieboldii is a component of several classic formulas such as "Chuan Xiong Cha Tiao San" and "Xinyi San," which are prescribed for symptoms including headache, nasal congestion, and sinusitis. The herb is believed to have properties that "dispel wind," "open the nasal orifices," and "alleviate pain."

Modern pharmacological studies on Asarum sieboldii are limited, but some research suggests that its volatile oils (such as methyl eugenol and safrole) may have anti-inflammatory and analgesic effects, potentially explaining its traditional use for headache and sinus symptoms. However, high-quality clinical trials validating these effects in humans are lacking, and concerns exist about toxicity with prolonged or high-dose use due to compounds like aristolochic acids.

In summary, the use of Asarum sieboldii for sinus-related headache is primarily justified by longstanding traditional practices in East Asian medicine, with a modest amount of in vitro or animal research offering partial support. Robust clinical evidence, however, is presently insufficient.