The use of the Matapalo tree (often referring to species of the Ficus or Strangler Fig genus) for the treatment of headaches, including sinus headaches, is primarily rooted in traditional medicine practices across various regions in Central and South America. Ethnobotanical surveys document that indigenous and rural communities sometimes use the bark, leaves, or latex of the Matapalo tree in topical preparations or infusions for the symptomatic relief of headaches. Such uses are passed down culturally and may be tied to the tree’s perceived general medicinal properties, including anti-inflammatory or analgesic effects attributed to its extracts in folk medicine. However, there is a lack of direct scientific studies or clinical trials validating the efficacy of Matapalo specifically for sinus headaches or even headaches more broadly. Existing pharmacological research on Ficus species sometimes notes general anti-inflammatory or antimicrobial activity, but these findings are not specific to headache treatment and have not been translated into evidence-based clinical recommendations. Therefore, while traditional use exists, scientific validation is minimal, and the reliability of its effect for sinus headache relief is questionable.