Pimpinella, particularly Pimpinella anisum (anise), has a long history of use in traditional medicine systems, especially in Europe, the Middle East, and Asia. It has been employed for a variety of ailments, among them respiratory complaints and headaches, including those associated with sinus congestion. Traditional herbalists have often recommended anise seeds or preparations made from Pimpinella for their purported anti-inflammatory, expectorant, and mild analgesic properties. In the context of sinus headache, these remedies are typically used to help clear nasal passages and alleviate the discomfort associated with sinus pressure and congestion.

However, the evidence for this use is primarily anecdotal and based on historical texts or folk practices. There are no robust clinical trials directly investigating the efficacy of Pimpinella species for sinus headaches specifically. Some laboratory studies suggest that extracts of Pimpinella anisum may have mild anti-inflammatory and antispasmodic effects, and there is limited evidence of antimicrobial activity, which could theoretically be beneficial in sinus-related ailments. Nevertheless, these findings have not been directly linked to relief of sinus headaches in controlled human studies. As such, while its use for sinus headache enjoys traditional backing, scientific validation remains minimal.