Premna, particularly species like Premna serratifolia, has a long history of use in traditional medicine systems such as Ayurveda, Siddha, and folk medicine across South and Southeast Asia. In these traditions, Premna leaves, roots, and bark are commonly used in decoctions, pastes, or as ingredients in polyherbal formulations to address various ailments, including headaches associated with sinus congestion. The rationale stems from its reputed anti-inflammatory, analgesic, and expectorant properties, which are believed to relieve sinus pressure and pain.

However, while laboratory studies have indicated that Premna extracts possess anti-inflammatory and analgesic effects, direct scientific studies evaluating its efficacy specifically for sinus headaches are lacking. Most supporting evidence remains anecdotal or is derived from its inclusion in classical formulations for respiratory and head-related ailments. There are no robust clinical trials or systematic reviews validating its use for this particular indication. Thus, while Premna's traditional application for sinus headache is well-documented, modern scientific validation is minimal to moderate at best, and the evidence is primarily historical rather than empirical.