The Sensitive Plant (Mimosa pudica) has a long history of use in traditional medicine systems, particularly in South and Southeast Asia. Ethnobotanical surveys document its use for a range of ailments, including headaches. In some traditional practices, leaves or roots are made into poultices or decoctions and applied to the forehead or consumed to relieve headache symptoms, sometimes specifically attributed to sinus issues. However, these uses are rooted in local and indigenous medicinal knowledge rather than scientific validation.

There is little to no clinical or pharmacological research specifically evaluating Mimosa pudica for the treatment of sinus headaches. While the plant contains various phytochemicals such as alkaloids, flavonoids, and tannins, which may exhibit anti-inflammatory or analgesic effects in general, there is no direct evidence linking these properties to efficacy against sinus headaches in humans. Most published research focuses on other potential uses, such as wound healing, antimicrobial, or anti-diarrheal activities. Thus, the use of Sensitive Plant for sinus headaches is supported primarily by tradition rather than robust scientific evidence.