Evidence supporting the use of: Diclofenac
For the health condition: Headache (tension)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is scientifically validated for use in treating various forms of pain, including headache. While its primary indications are for musculoskeletal pain, there is substantial evidence supporting its efficacy in the management of tension-type headaches. Several randomized controlled trials and systematic reviews have investigated the use of diclofenac, especially in the form of oral or soluble preparations, for acute headache relief. Diclofenac works by inhibiting cyclooxygenase (COX) enzymes, leading to reduced synthesis of prostaglandins, which play a key role in pain and inflammation.

The clinical literature shows that diclofenac is effective in reducing the intensity and duration of headache pain compared to placebo and is comparable to other NSAIDs such as ibuprofen. For example, a Cochrane review (Derry et al., 2012) analyzing NSAIDs for acute tension-type headache found that diclofenac provided significant pain relief for many patients. The typical dosage used in studies is 50 mg orally, which has demonstrated a favorable efficacy and safety profile.

Therefore, diclofenac's use for tension-type headache is supported by scientific evidence, and it is recognized as an option in clinical guidelines for the acute treatment of this condition, particularly in patients who cannot tolerate other NSAIDs or paracetamol. However, as with all NSAIDs, risks such as gastrointestinal or cardiovascular side effects must be considered.

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